Towards biomarker-based tests that can facilitate decisions about prevention and management of preeclampsia in low-resource settings

Author:

Acestor Nathalie,Goett Jane,Lee Arthur,Herrick Tara M.,Engelbrecht Susheela M.,Harner-Jay Claudia M.,Howell Bonnie J.,Weigl Bernhard H.

Abstract

AbstractIn recent years, an increasing amount of literature is emerging on candidate urine and blood-based biomarkers associated with incidence and severity of preeclampsia (PE) in pregnant women. While enthusiasm on the usefulness of several of these markers in predicting PE is evolving, essentially all work so far has focused on the needs of high-resource settings and high-income countries, resulting primarily in multi-parameter laboratory assays based on proteomic and metabolomics analysis techniques. These highly complex methods, however, require laboratory capabilities that are rarely available or affordable in low-resource settings (LRS). The importance of quantifying maternal and perinatal risks and identifying which pregnancies can be safely prolonged is also much greater in LRS, where intensive care facilities that can rapidly respond to PE-related health threats for women and infants are limited. For these reasons, simple, low cost, sensitive, and specific point-of-care (POC) tests are needed that can be performed by antenatal health care providers in LRS and that can facilitate decisions about detection and management of PE. Our study aims to provide a comprehensive systematic review of current and emerging blood and urine biomarkers for PE, not only on the basis of their clinical performance, but also of their suitability to be used in LRS-compatible test formats, such as lateral flow and other variants of POC rapid assays.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Reference124 articles.

1. Impaired endothelial function and elevated levels of pentraxin in early - onset preeclampsia;Hamad;Acta Obstet Gynecol Scand,2012

2. Urinary prolactin as a reliable marker for preeclampsia its severity and the occurrence of adverse pregnancy outcomes;Leaños;J Clin Endocrinol Metab,2008

3. von Diagnostic accuracy of urinary spot protein : creatinine ratio for proteinuria in hypertensive pregnant women systematic;Côté;AM review Med,2008

4. Recent advances in the understanding of the pathophysiology of preeclampsia;Warrington;Hypertension,2013

5. IM ST predates proteinuria and clinical features of preeclampsia : longitudinal prospective study;Craici;Hypertension,2013

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