Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis

Abstract

AbstractBackground:Although several studies have explored the genetic polymorphisms of apolipoprotein E (Methods:All relevant case-control studies and cohort studies published in Chinese or English prior to March 2016 were searched for in electronic databases. Detailed information concerning each piece of literature was independently extracted by two researchers. We used STATA11.0 to process all data and to determine the pooled odds ratio (OR). Altogether, four genetic models were applied to calculate OR and 95% confidence interval (CI): (1)Results:Eighteen studies concerningConclusions:Our investigation supported the fact that the