Erroneous HbA1c measurements in the presence of β-thalassemia and common Chinese hemoglobin variants

Abstract

AbstractHbABlood samples from normal patients, patients with β-thalassemia, patients exhibiting heterozygosity, and patients exhibiting homozygosity were analyzed using ion-exchange HPLC (Variant II Turbo, Bio-Rad and Adams ASamples from patients with β-thalassemia produced significant positive biases on the Variant II Turbo system compared to the other three systems. For heterozygous βA/βE patients, a good agreement was observed between Capillarys 2 Flex Piercing and Ultraβ-Thalassemia can cause errors in HbA