Abstract
AbstractThe reliable detection of paraprotein in serum and urine is the primary purpose of electrophoretic procedures in clinical laboratories. Screening immunofixation electrophoresis (sIFE) employs a single application of antisera directed against heavy and light chains that facilitates the detection of paraproteins that migrate in the non-γ region or that are below the detection limit of protein electrophoresis. These paraproteins that are missed by routine electrophoresis occur in up to 27.3% of newly investigated and 13.6% of monitored patients. Small paraproteins missed by conventional electrophoretic techniques are clinically important in the diagnosis and monitoring of malignant plasma and B-cell disorders. The superior diagnostic performance of sIFE makes it suitable as the initial laboratory procedure to investigate paraproteins in complex serum and urine matrices.
Subject
Biochemistry, medical,Clinical Biochemistry,General Medicine
Reference38 articles.
1. website http www cancerresearchuk org health professional cancer statistics statistics by cancer type myeloma incidence Last accessed;July;Cancer Research
2. The Ulysses syndrome;Can Med Assoc J,1972
3. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma;Lancet Oncol,2014
4. IgD myeloma protein with unreactive light chain determinants;Clin Chem,1979
5. Monoclonal gammopathy of undetermined significance;Br J Haematol,2006
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