Characteristics of Chinese patients with antiphospholipid syndrome and the ability of lupus anticoagulant assays to identify them

Abstract

AbstractBackground:The objective of the work was to study the manifestations of antiphospholipid syndrome (APS) in the Chinese population, and evaluate the ability of lupus anticoagulant (LAC) assays to identify APS.Methods:Consecutive patients with APS from 2012 to 2015 in our hospital were recruited, strictly following the Sydney revised Sapporo criteria for APS classification. Meanwhile, in the LAC-positive population, LAC normalized ratios obtained from diluted Russell viper venom time (DRVVT) and silica clotting time (SCT) assays were compared between patients with and without APS.Results:One hundred and seventeen patients with defined APS comprised 86 women and 31 men with a mean age of 38 years (range 9–78 years), 38 (32.5%) of them had systemic lupus erythematosus. The prevalence of arterial thrombosis, venous thrombosis and obstetric complications were 46.2%, 25.6% and 30.8%, respectively. LAC was detected in 105 patients (89.7%), anti-βConclusions:A high prevalence of arterial thrombosis and LAC-positive result was noted in Chinese patients with APS, and an appropriate threshold for LAC normalized ratios could help to discriminate APS from non-APS patients in the LAC-positive population.