Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy-Reference-Cited by-同舟云学术

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Published:2023-02-01 Issue:1 Volume:3 Page:4-30
ISSN:2749-9642
Container-title:Medical Review
language:en
Short-container-title:

Author:

Su Yuanzhen¹²³,Jin Guanyu²⁴,Zhou Huicong²,Yang Zhaofan²,Wang Lanqing²,Mei Zi²,Jin Qionghua⁴,Lv Shixian²^ORCID,Chen Xuesi¹²³^ORCID

Affiliation:

1. Key Laboratory of Polymer Ecomaterials , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , China

2. School of Materials Science and Engineering , Peking University , Beijing , China

3. School of Applied Chemistry and Engineering , University of Science and Technology of China , Hefei , Anhui Province, China

4. Department of Chemistry , Capital Normal University , Beijing , China

Abstract

Abstract The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/mr-2022-0048/pdf

Reference192 articles.

1. Xia, C, Dong, X, Li, H, Cao, M, Sun, D, He, S, et al.. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J 2022;135:584–90. https://doi.org/10.1097/cm9.0000000000002108.

2. Spill, F, Reynolds, DS, Kamm, RD, Zaman, MH. Impact of the physical microenvironment on tumor progression and metastasis. Curr Opin Biotechnol 2016;40:41–8. https://doi.org/10.1016/j.copbio.2016.02.007.

3. Arneth, B. Tumor microenvironment. Medicina 2020;56:15. https://doi.org/10.3390/medicina56010015.

4. Fukumura, D, Jain, RK. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem 2007;101:937–49. https://doi.org/10.1002/jcb.21187.

5. Huang, J, Zhang, L, Wan, D, Zhou, L, Zheng, S, Lin, S, et al.. Extracellular matrix and its therapeutic potential for cancer treatment. Signal Transduct Targeted Ther 2021;6:153. https://doi.org/10.1038/s41392-021-00544-0.

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