Developmental origins of adult diseases-Reference-Cited by-同舟云学术

Developmental origins of adult diseases

Published:2022-10-01 Issue:5 Volume:2 Page:450-470
ISSN:2749-9642
Container-title:Medical Review
language:en
Short-container-title:

Author:

Mo Jiaying¹²,Liu Xuanqi²,Huang Yutong²,He Renke¹²,Zhang Yu³,Huang Hefeng¹²³⁴^ORCID

Affiliation:

1. Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital , International Institutes of Medicine, Zhejiang University School of Medicine , Yiwu , Zhejiang Province , China

2. The Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education , Zhejiang University School of Medicine , Hangzhou , Zhejiang Province , China

3. Obstetrics and Gynecology Hospital , Institute of Reproduction and Development, Fudan University , Shanghai , China

4. Research Units of Embryo Original Diseases , Chinese Academy of Medical Sciences (No. 2019RU056) , Shanghai , China

Abstract

Abstract The occurrence and mechanisms of developmental adult diseases have gradually attracted attention in recent years. Exposure of gametes and embryos to adverse environments, especially during plastic development, can alter the expression of certain tissue-specific genes, leading to increased susceptibility to certain diseases in adulthood, such as diabetes, cardiovascular disease, neuropsychiatric, and reproductive system diseases, etc. The occurrence of chronic disease in adulthood is partly due to genetic factors, and the remaining risk is partly due to environmental-dependent epigenetic information alteration, including DNA methylation, histone modifications, and noncoding RNAs. Changes in this epigenetic information potentially damage our health, which has also been supported by numerous epidemiological and animal studies in recent years. Environmental factors functionally affect embryo development through epimutation, transmitting diseases to offspring and even later generations. This review mainly elaborated on the concept of developmental origins of adult diseases, and revealed the epigenetic mechanisms underlying these events, discussed the theoretical basis for the prevention and treatment of related diseases.

Funder

National Natural Science Foundation of China

Collaborative Innovation Program of Shanghai Municipal Health Commission

Shanghai Frontiers Science Research Base of Reproduction and Development

CAMS Innovation Fund for Medical Sciences

Clinical Research Plan of SHDC

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/mr-2022-0027/pdf

Reference216 articles.

1. Barker, DJ, Osmond, C, Law, CM. The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health 1989;43:237–40. https://doi.org/10.1136/jech.43.3.237.

2. Hanson, MA, Gluckman, PD. Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev 2014;94:1027–76. https://doi.org/10.1152/physrev.00029.2013.

3. Safi-Stibler, S, Gabory, A. Epigenetics and the developmental origins of health and disease: parental environment signalling to the epigenome, critical time windows and sculpting the adult phenotype. Semin Cell Dev Biol 2020;97:172–80.

4. Simeoni, U, Armengaud, JB, Siddeek, B, Tolsa, JF. Perinatal origins of adult disease. Neonatology 2018;113:393–9. https://doi.org/10.1159/000487618.

5. Tioleco, N, Silberman, AE, Stratigos, K, Banerjee–Basu, S, Spann, MN, Whitaker, AH, et al.. Prenatal maternal infection and risk for autism in offspring: a meta–analysis. Autism Res 2021;14:1296–316. https://doi.org/10.1002/aur.2499.