Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control-Reference-Cited by-同舟云学术

Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control

Published:2022-09-14 Issue:5 Volume:2 Page:531-540
ISSN:2749-9642
Container-title:Medical Review
language:en
Short-container-title:

Author:

Jiang Hong¹²^ORCID

Affiliation:

1. Department of Neurobiology, School of Basic Medical Sciences , Neuroscience Research Institute, Peking University , Beijing , China

2. Key Laboratory for Neuroscience, Ministry of Education/National Health Commission of China , Peking University , Beijing , China

Abstract

Abstract Gamma-aminobutyric acid (GABAergic) neuron, as one of important cell types in synaptic transmission, has been widely involved in central nervous system (CNS) regulation of organismal physiologies including cognition, emotion, arousal and reward. However, upon their distribution in various brain regions, effects of GABAergic neurons in the brain are very diverse. In current report, we will present an overview of the role of GABAergic mediated inhibitory neurocircuitry in the hypothalamus, underlying mechanism of feeding and sleep homeostasis as well as the characteristics of latest transcriptome profile in order to call attention to the GABAergic system as potentially a promising pharmaceutical intervention or a deep brain stimulation target in eating and sleep disorders.

Funder

China Fundamental Research Funds for the Central Universities

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/mr-2022-0022/pdf

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