In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines-Reference-Cited by-同舟云学术

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

Published:2016-12-01 Issue:4 Volume:66 Page:497-508
ISSN:1820-7448
Container-title:Acta Veterinaria
language:en
Short-container-title:

Author:

Krstić P. Milena¹,Borozan Z. Sunčica¹,Sovilj P. Sofija²,Grgurić-Šipka R. Sanja²,Oljarević M. Jelena²

Affiliation:

1. Department of Chemistry, Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia

2. Deparment of General and Inorganic Chemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia

Abstract

Abstract The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.

Publisher

Walter de Gruyter GmbH

Subject

General Veterinary

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