Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex-Reference-Cited by-同舟云学术

Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

Published:2016-12-01 Issue:4 Volume:66 Page:489-496
ISSN:1820-7448
Container-title:Acta Veterinaria
language:en
Short-container-title:

Author:

Bai-Shuang Yin¹²,Gao Li³,Lian-Jun Fu⁴,Ying Fu⁴,Wan-Li Sha¹²,Guo-Jiang Li¹²,Hong-Bin Wang³

Affiliation:

1. Department of Veterinary Science, Jilin Agriculture Science and Technology College, Jilin 132101, China China

2. Key Lab of Preventive Veterinary Medicine in Jilin Province, Jilin 132101, China

3. College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China

4. Department of Veterinary Science, Jilin Agriculture Science and Technology College, Jilin 132101, China

Abstract

Abstract The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Westernblot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.

Publisher

Walter de Gruyter GmbH

Subject

General Veterinary

Reference34 articles.

1. 1. Kiyoshige T, Takashi S, Mitsuhiko M: The comparison of effects of various anesthetics on expression of Fos protein in the rat brain. Neuroscience Letter 1994, 176(1): 59-62.

2. 2. Mitcheltree DH, Serfass WM, Tzilkowski RL, Peper MT, Whary RP: Physiological responses of fishers to immobilization with ketamine, ketamine-xylazine, or Telazol. Wildlife Society Bulletin 1999, 27(3): 582-591.

3. 3. Golden HN, Shults BS, Kunkel KE: Immobilization of wolverines with Telazol from a helicopter. Wildlife Society Bulletin 2002, 30(2): 492-497.

4. 4. Janovsky M, Tataruch F, Ambuehl M, Giacometti M: A Zoletil®-Rompun® mixture as an alternative to the use of opioids for immobilization of feral red deer. Journal of Wildlife Diseases 2000, 36(4): 663-669.

5. 5. Hellyer P, Muir WW, Hubbell JA, Sally J: Cardio respiratory effects of the intravenous administration of tiletamine-zolazepam to cats. Veterinary Surgery 1988, 17(7): 105-110.