Design, synthesis and antibacterial evaluation of 2-alkyl- and 2-aryl-3-(phenylamino)quinazolin-4(3H)-one derivatives-Reference-Cited by-同舟云学术

Design, synthesis and antibacterial evaluation of 2-alkyl- and 2-aryl-3-(phenylamino)quinazolin-4(3H)-one derivatives

Published:2017-04-01 Issue:2 Volume:23 Page:105-108
ISSN:2191-0197
Container-title:Heterocyclic Communications
language:
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Author:

Mohammadi Ali Asghar¹,Ahdenov Reza¹,Abolhasani Sooki Ali²

Affiliation:

1. 1Department of Chemistry, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran

2. 2Shaheed Beheshti University, Academic Center for Education, Culture, and Research, Research Institute of Applied Sciences, Tehran, Iran

Abstract

Abstract2-Alkyl and 2-aryl-3-(phenylamino)quinazolin-4(3H)-ones 4a–h were synthesized in a one-pot three-component condensation of an isatoic anhydride 1a–h, ethyl or methyl ortho ester and phenylhydrazine in the presence of KAl(SO4)2·12H2O (alum) as a nontoxic, reusable, inexpensive and easily available catalyst. The synthesis was conducted under microwave irradiation or classical heating. Products 4a and 4b show good antimicrobial activities.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2016-0201/pdf

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