Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion-Reference-Cited by-同舟云学术

Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion

Published:2022-09-15 Issue:5 Volume:47 Page:633-639
ISSN:1303-829X
Container-title:Turkish Journal of Biochemistry
language:en
Short-container-title:

Author:

Emre Bostanci Meriç¹^ORCID,Hepokur Ceylan²^ORCID,Caner Armağan³⁴^ORCID,Can Mollaoğlu Murat¹^ORCID,Karadayi Kürşat⁵^ORCID

Affiliation:

1. Department of Surgical Oncology , Sivas Numune Hospital , Sivas , Turkey

2. Faculty of Pharmacy, Department of Biochemistry , Sivas Cumhuriyet University , Sivas , Turkey

3. Faculty of Medicine, Department of Biophysics , Erciyes University , Kayseri , Turkey

4. Erciyes University, Betul Ziya Eren Stem Cell and Genome Center , Kayseri , Turkey

5. Faculty of Medicine, Department of Surgical Oncology , Sivas Cumhuriyet University , Sivas , Turkey

Abstract

AbstractObjectivesMesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia, the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. Clinoptilolite is one of the most abundant natural zeolites, and it is used for its ion exchange and adsorbent properties. Clinoptilolite has been reported to have an immune-enhancing, anti-carcinogenic, and antioxidant effectin-vitro/in-vivostudies. Clinoptilolite’s histological and biochemical effects on ischemic small intestines.MethodsThe experimental animals were randomly divided into sham, control, and clinoptilolite treatment group. Clinoptilolite was administered intraperitoneally after ischemia/reperfusion. Cardiac blood was stored for biochemical analysis. Total antioxidant levels and total oxidant levels were analyzed from the sera taken from groups. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expressions in blood samples were determined by RT-qPCR. At the end of the reperfusion, terminal ileum tissues were taken for histological tests.ResultsThe mean TNF-α expression level was 3.89 in the control group and 2.91 in the clinoptilolite treatment group. The mean IL-6 expression levels were 2.32 in the control group and 1.49 in the clinoptilolite treatment group.Conclusionsclinoptilolite administration provided healing in the rat ischemia-reperfusion injury model.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/tjb-2021-0244/pdf

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