Impact of serum 25 hydroxyvitamin D deficiency on lipid biomarkers in established coronary artery disease-Reference-Cited by-同舟云学术

Impact of serum 25 hydroxyvitamin D deficiency on lipid biomarkers in established coronary artery disease

Published:2021-09-16 Issue:0 Volume:0 Page:
ISSN:1303-829X
Container-title:Turkish Journal of Biochemistry
language:en
Short-container-title:

Author:

Yassir Shaheena¹^ORCID,Ramarajan Madan Gopal²³,Patil Seema⁴,Shaikh Shaheen B.¹^ORCID,Abdulla Yassir M.⁵,Manjrekar Poornima A.³⁶^ORCID

Affiliation:

1. Department of Biochemistry , Yenepoya Medical College , Yenepoya (Deemed to be University) , Derelakatte , Mangalore , Karnataka , India

2. Institute of Bioinformatics , Bangalore , Karnataka , India

3. Manipal Academy of Higher Education , Manipal , Karnataka , India

4. Department of Statistics , Yenepoya (Deemed to be University ), Mudipu , Mangalore , Karnataka , India

5. Department of Radiodiagnosis , Srinivas Institute of Medical Sciences and Research Centre , Mangalore , Karnataka , India

6. Department of Biochemistry , Kasturba Medical College , Mangalore , Manipal Academy of Higher Education , Manipal , Karnataka , India

Abstract

Abstract Objectives Vitamin D deficiency (VDD) is associated with coronary artery disease (CAD) directly by augmenting atherosclerosis and indirectly through cardiovascular risk factors. The present study was aimed to find an association of 25 hydroxyvitamin D (25(OH)D) with lipid profile among established CAD. Methods A cross-sectional study was conducted among 73 patients of angiographically confirmed CAD aged between 35 and 55 years of both gender. Serum 25(OH)D and lipid profile were estimated by ELISA kit and Roche autoanalyzer respectively. Atherogenic index of plasma (AIP) and sdLDL (small dense low-density lipoprotein) were calculated using the accepted formula. Results The mean 25(OH)D level was 17.95 ± 13.51. Only 15% had sufficient 25(OH)D level. There was a significant negative correlation of 25(OH)D with TC/HDL (T.cholesterol/High-density lipoprotein) ratio (p=0.022). Multivariate logistic regression analysis showed no statistically significant impact of 25(OH)D with lipid biomarkers. Conclusions We found low 25(OH)D mean value among CAD and a significant negative correlation of 25(OH)D with TC/HDL. This study suggests VDD may affect primary lipid target resulting in unfavorable outcomes in CAD.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/tjb-2021-0148/pdf

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