KIM-1 and GADDI-153 gene expression in paracetamol-induced acute kidney injury: effects of N-acetylcysteine, N-acetylmethionine, and N-acetylglucosamine-Reference-Cited by-同舟云学术

KIM-1 and GADDI-153 gene expression in paracetamol-induced acute kidney injury: effects of N-acetylcysteine, N-acetylmethionine, and N-acetylglucosamine

Published:2021-12-28 Issue:0 Volume:0 Page:
ISSN:1303-829X
Container-title:Turkish Journal of Biochemistry
language:en
Short-container-title:

Author:

Mohamed Nahed A.¹^ORCID,Hassan Mohammed H.²^ORCID,Saleem Tahia H.¹^ORCID,Mohamed Sotohy A.³^ORCID,El-Zeftawy Marwa⁴⁵^ORCID,Ahmed Eman A.⁴^ORCID,Mostafa Nashwa A. M.⁶^ORCID,Hetta Helal F.⁷^ORCID,Hasan Al Shaimaa⁸,Abdallah Ahmed Alamir Mahmoud⁹^ORCID

Affiliation:

1. Department of Medical Biochemistry, Faculty of Medicine, Assiut University , Assiut , Egypt

2. Department of Medical Biochemistry, Faculty of Medicine, South Valley University , 83523 Qena , Egypt

3. Animal and Environmental Hygiene, Faculty of Veterinary Medicine, Assiut University , Assiut , Egypt

4. Biochemistry Department, Faculty of Veterinary Medicine, New Valley University , New Valley , Egypt

5. Biological Screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University , Alexandria , Egypt

6. Department of Histology, Faculty of Medicine, Assiut University , Assiut , Egypt

7. Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University , Assiut , Egypt

8. Department of Medical Pharmacology, Faculty of Medicine, South Valley University , Qena , Egypt

9. Department of Medical Biochemistry, Faculty of Medicine, Sohag University , Sohag , Egypt

Abstract

Abstract Objectives Acute kidney injury (AKI) is a critical clinical event characterized by a reduction in the excretory function of the kidneys. N-acetylcysteine (NAC), N-acetylmethionine (NAM) and N-acetylglucosamine (NAG) are antioxidants with scanty known genetic mechanisms. We aimed to assess both kidney injury molecule-1 (KIM-1) and growth-arrested DNA damage-inducible gene-153 (GADD-153) genes expression in paracetamol (PA) induced AKI. Also, to recognize whether NAC, NAM and/or NAG have roles in altering the expression of these genes for ameliorating the AKI induced by PA. Methods The present preliminary study achieved the AKI model by oral administration of PA therapeutic dose for 15 days in experimental male rats. Serum urea, creatinine, and renal oxidative stress parameters were analyzed. Genetic expression of KIM-1 and GADD-153 were determined using real time-PCR. Results Significant elevations of serum urea, creatinine and nitric oxide in renal tissue after PA administration; however, total thiol content was reduced. In addition, both KIM-1 and GADD-153 were upregulated. These biochemical alterations were improved after using NAC and partially after NAM; however, NAG had little effect. Conclusions Up-regulation of both KIM-1 and GADD-153 occur in AKI induced by PA, which was significantly reversed by NAC.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/tjb-2021-0233/pdf

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