Abietane Diterpenoids and a Lignan from Pinus yunnanensis

Abstract

Two new abietane diterpene acids, pinyunins A (1) and B (2), a new lignan, 2-[2-hydroxy-5-(3- hydroxypropyl)-3-methoxyphenyl]-1-(2,3-dihydroxyphenyl)propane-1,3-diol (3), and eight known diterpenoids (4 - 11) were isolated from the bark of Pinus yunnanensis Franch. Their structures were elucidated by spectroscopic methods. Compounds 1 - 3 exhibited high inhibitions on Cox-2 (> 80 %) and low inhibitions on Cox-1 (< 50%), showing the trend of selective inhibition of Cox-2, while the positive controls NS-398 (Cox-2) and SC-560 (Cox-1) gave inhibitions of 97.09% and 61.30 %, respectively. Compounds 1 - 11 were evaluated for their cytotoxicity against five human cancer cell lines with Cisplatin as a positive control.