Selectfluor-triggered C–H halogenations of enaminones with copper(I) halide (CuX) for the synthesis of 3-halochromones-Reference-Cited by-同舟云学术

Selectfluor-triggered C–H halogenations of enaminones with copper(I) halide (CuX) for the synthesis of 3-halochromones

Published:2024-09-03 Issue: Volume: Page:
ISSN:0932-0776
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Ma Tian¹²,Li Xiaoli³,Yuan Jinwei³

Affiliation:

1. Water Environment and Health Henan Engineering Technology Research Center , Zhengzhou 451100 , P. R. China

2. School of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology , Xinzheng 451100 , P. R. China

3. College of Environmental Engineering, Henan University of Technology , Zhengzhou 450001 , P. R. China

Abstract

Abstract A practical and efficient synthetic route to construct a variety of 3-halochromones has been realized using Selectfluor reagent as a fluorine source, or Selectfluor-copper(I) halide combination as halogen source under mild conditions. This reaction proceeds via a sequence of electrophilic cation addition, and cyclization leading to a broad range of 3-halochromones in good to excellent yields in a short period of time. Additionally, the utilization of commercially available and cost-effective Selectfluor and copper(I) halide renders this system highly practical.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/znb-2024-0027/pdf

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