Synthesis and characterization of PCU@C-Ag/AgCl nanoparticles as an antimicrobial material for respiratory tract infection

Author:

Palanisamy Senthilkumar1,Subramanian Kalaivani2,Bennet Lerince Godrina2,Ambrose Janani2,Gopalakrishnan Aganiya2,Babu Sudhagar3,Rajamani Ranjithkumar4,Jha Niraj Kumar5,Pandit Soumya6,Singh Sachin Kumar7,Dua Kamal8,Gupta Piyush Kumar9

Affiliation:

1. Department of Biotechnology , Nehru Arts and Science College , Coimbatore – , Tamil Nadu , India

2. Department of Biotechnology , Kongunadu Arts and Science College , Coimbatore – , Tamil Nadu , India

3. Structural Biology Laboratory , Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore – , Karnataka , India

4. Viyen Biotech LLP , Coimbatore – , Tamil Nadu , India

5. Department of Biotechnology, School of Engineering and Technology (SET) , Sharda University, Knowledge Park III , Greater Noida – 201310 , Uttar Pradesh , India

6. Department of Life Sciences, School of Basic Sciences and Research (SBSR) , Sharda University, Knowledge Park III , Greater Noida – 201310 , Uttar Pradesh , India

7. School of Pharmaceutical Sciences , Lovely Professional University , Phagwara – 144411 , Punjab , India

8. Discipline of Pharmacy, Graduate School of Health , University of Technology Sydney , NSW 2007 , Australia ; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine , University of Technology Sydney , Ultimo, 2007 New South Wales , Australia

9. Department of Life Sciences, School of Basic Sciences and Research (SBSR) , Sharda University, Knowledge Park III , Greater Noida – 201310 , Uttar Pradesh , India ; Email: dr.piyushkgupta@gmail.com

Abstract

Abstract The pregnant cow urine (PCU) is an active source of antimicrobial agents that is used for fabricating chitosan coated Ag/AgCl nanoparticles (NPs) in the present study. These PCU@C-Ag/AgCl NPs were physicochemically characterized and evaluated for antimicrobial activity against selected respiratory tract infection (RTI) pathogens. The absorption band around 420 nm in UV-Visible spectrum indicated the presence of Ag NPs. The spherical shape of NPs was observed using TEM. Also, the crystalline structure was confirmed using the XRD pattern. The PCU@C-Ag/AgCl NPs showed strong antimicrobial activity against all tested RTI pathogens. In addition, FESEM analysis showed morphological changes in RTI bacterial pathogens. Thereby, PCU@C-Ag/AgCl NPs may be used as an antimicrobial material to treat RTIs in near future at clinical level.

Publisher

Walter de Gruyter GmbH

Subject

General Earth and Planetary Sciences,General Environmental Science

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