Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long COVID

Author:

Guo Ming1ORCID,Shang Shunlai12,Li Mengfei1,Cai Guangyan1,Li Ping1,Chen Xiangmei13,Li Qinggang1ORCID

Affiliation:

1. Department of Nephrology, First Medical Center of Chinese PLA General Hospital , State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research , Beijing 100853 , China

2. Department of Nephrology , China-Japan Friendship Hospital , Beijing , China

3. Haihe Laboratory of Cell Ecosystem , China

Abstract

Abstract COVID-19 posed a major challenge to the healthcare system and resources worldwide. The popularization of vaccines and the adoption of numerous prevention and control measures enabled the gradual end of the COVID-19 pandemic. However, successive occurrence of autoimmune diseases in patients with COVID-19 cannot be overlooked. Long COVID has been the major focus of research due to the long duration of different symptoms and the variety of systems involved. Autoimmunity may play a crucial role in the pathogenesis of long COVID. Here, we reviewed several autoimmune disorders occurring after COVID-19 infection and the pathogenesis of long COVID.

Funder

National Key R&D Program of China

International Association of Chinese Nephrologists Research Grant

Haihe Laboratory of Cell Ecosystem Innovation Fund

China Postdoctoral Science Foundation

Cross-sectional project of China-Japan Friendship Hospital

Beijing Natural Science Foundation

National Natural Science Foundation of China

Young Elite Scientists Sponsorship Program by CAST

the Open Grant from the Pingyuan Laboratory

Publisher

Walter de Gruyter GmbH

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