The role of bile acids in human aging
Author:
Jin Lihua1ORCID, Shi Linsen1, Huang Wendong12ORCID
Affiliation:
1. Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute , City of Hope National Medical Center , Duarte , CA , USA 2. Irell & Manella Graduate School of Biomedical Science , City of Hope National Medical Center , Duarte , CA , USA
Abstract
Abstract
Bile acids are recognized as important signaling molecules that enable fine-tuned inter-communication from the liver, through the intestine, to virtually any organ, thus encouraging their pleiotropic physiological effects. Aging is a complex natural process defined as a progressive decline in cellular and organismal functions. A causal link between bile acids and the aging process is emerging. However, there are gaps in our understanding of the molecular mechanisms and precise targets responsible for the alteration of bile acid profiles and their role in the aging process. Intestinal barrier dysfunction leads to endotoxemia, systemic inflammation, insulin resistance, diabetes, lipid accumulation, obesity and fatty liver diseases, and health decline and death. In fact, intestinal barrier dysfunction is suggested to be an evolutionarily conserved hallmark of aging. Bile acids may modulate the aging process by regulating intestinal barrier integrity.
Funder
COH AR-DMRI Innovative Award Program City of Hope
Publisher
Walter de Gruyter GmbH
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