Antioxidant and antibacterial effects of a new macrocyclic bis(bibenzyl) ether from Combretum molle (Combretaceae)
Author:
Yakai Fawai12, Dawe Amadou32, Manshuk Ibrayeva4, Taira Vincent12, Wangso Albert12, Fanta Angele12, Doudja Chantal12, Loura Benoit42
Affiliation:
1. Department of Chemistry, Faculty of Science , 310136 University of Maroua , P.O. Box 814 , Maroua , Cameroon 2. Department of Refining and Petrochemistry, Faculty of Mines and Petroleum Industries , University of Maroua , P.O. Box 08 , Kaélé , Cameroon 3. Department of Chemistry, Higher Teachers Training College , 310136 University of Maroua , P.O. Box 55 , Maroua , Cameroon 4. Department of Natural Sciences, Faculty of Science and Technology , Caspian University of Technology and Engineering , P.O. Box 130000 , Aktau , Kazakhstan
Abstract
Abstract
A new compound, combrebisbibenzyl (1) as well as two sterols including stigmasterol (2) and 3-O-β-D-glucopyranoside of β-sitosterol (3) and seven triterpenoids namely mollic acid (4), oleanolic acid (5), ursolic acid (6), arjunglucoside I (7), arjungenin (8), bellericagenin B (9) and combregenin (10) were isolated from the root of Combretum molle. Compounds 1, 7 and 9, AcOEt and MeOH extracts exhibited moderate antioxidant activity with an IC50 value of 179.32, 185.21, 195.11 197.41 and 170.21 μg/mL, respectively, for reactive oxygen species inhibition and, inhibition percent value of 57.23, 64.52, 53.55, 67.42 and 65.04, respectively, for DPPH free-radical scavenging. The E. MeOH presented a moderate antibacterial activity against Staphylococcus aureus with DIZs value of 10.1 ± 0.2 from 800 μg/mL while the others tested strains were not sensitive. However, most of the tested bacteria, (S. aureus, Escherichia coli and Salmonella typhimurium) were moderately sensitive to E. AcOEt from 800 μg/mL with DIZs value of 8.2 ± 0.1. From the E. AcOEt, five of the isolated compounds were tested against four bacteria strains using the disc-dilusion method. The results showed that compound 1 and 2 exhibited very good antibacterial activity against all the tested bacteria at the concentration of 30 μg/mL with respective DIZ value of 22.2 and 25.4 for E. coli, 20.2 and 30.2 for S. typhimurium, 22.3 and 23.1 for S. aureus and, 22.1 and 24.1 for Streptococcus faecalis. This antibacterial activity significantly depends on the concentration.
Publisher
Walter de Gruyter GmbH
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