Phylogeny and Biotransformation. Part 5*: Biotransformation of Isopinocampheol

Abstract

Abstract Biotransformation of isopinocampheol with 100 bacterial and fungal strains yielded 1-, 2-, 4-, 5-, 7-, 8 - and 9-hydroxy-isopinocampheol besides three rearranged monoterpenes, one of them bearing the novel isocarane skeleton. A pronounced enantioselectivity between (+)- and (-)-isopinocampheol was observed. The phylogenetic position of the individual strains could be seen in their ability to form the products from (+)-isopinocampheol. The formation of 1,3-dihydroxypinane is a domain of bacteria, while 3,5- or 3,7-dihydroxypinane was mainly formed by fungi, especially those of the phylum Zygomycotina. The activity of Basidiomycotina towards oxidation of isopinocampheol was rather low. Such informations can be used in a more effective selection of strains for screening.