CGF treatment of leg ulcers: A randomized controlled trial-Reference-Cited by-同舟云学术

CGF treatment of leg ulcers: A randomized controlled trial

Published:2019-12-24 Issue:1 Volume:14 Page:959-967
ISSN:2391-5463
Container-title:Open Medicine
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Author:

Amato Bruno¹²,Farina Michele Angelo³,Campisi Silvana⁴,Ciliberti Marino⁵,Donna Vincenzo Di⁶,Florio Anna⁷,Grasso Antonino⁸,Miranda Rosario⁹,Pompeo Francesco¹⁰,Farina Eleonora³,Serra Raffaele²¹¹,Cirocchi Roberto¹²,Calemma Francesca¹,Rocca Aldo¹³,Compagna Rita²⁷

Affiliation:

1. Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy

2. Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy

3. Vascular Surgery Unit, Villa Del Sole Hospital81100Caserta, Italy

4. Transfusion Immunohematology Service, S.Andrea Hospital, 00192Rome, Italy

5. Ulcer Service Program, Castellammare Di Stabia, Naples, Italy

6. Medical Center Regeneration Home, Corato, Foggia,Italy

7. Department of Cardio-thoracic and Respiratory Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

8. Vascular Surgery Unit, University of Catania, “Policlinico, Vittorio Emanuele” P.O. G. Rodolico , Catania, Italy

9. Angiology Service ASL NA 3 Sud, Nola District, 80035 Nola, Napoli, Italy

10. Vascular Surgery Unit, Neurologic Mediterranean Institute Neuromed, 86077 Pozzilli, Isernia, Italy

11. Department of Medical and Surgical Science, University Magna Graecia of Catanzaro, Catanzaro, Italy

12. Department of Surgical and Biomedical Sciences, Division of Week surgery, S. Maria Hospital, Terni, Italy

13. Department of Clinical Medicine and Surgery, University Federico II of Naples, Italy, via S. Pansini, 5, 80131Naples, Italy

Abstract

AbstractBackgroundConcentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers.AimThe aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process.MethodsAutologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study.ResultsThe results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities.ConclusionsThese results support the CGF’s clinical use for improving clinical outcomes in mixed ulcers of the legs.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Link

https://www.degruyter.com/document/doi/10.1515/med-2019-0113/pdf

Reference56 articles.

1. Low molecular weight heparin improves healing of chronic venous ulcers especially in the elderly;Int. Wound J,2015

2. A proposed protocol for the standardized preparation of PRF membranes for clinical use;Biologicals,2012

3. Preparation of autologous platelet-rich gel for diabetic refractory dermal ulcer and growth factors analysis from it;Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi,2008

4. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields;Biomaterials,2007

5. Growthpromoting action and growth factor release by different platelet derivatives;Platelets,2014

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