Robust growth hormone responses to GH-releasing peptide 2 in adolescents-Reference-Cited by-同舟云学术

Robust growth hormone responses to GH-releasing peptide 2 in adolescents

Published:2024-07-04 Issue:8 Volume:37 Page:730-733
ISSN:0334-018X
Container-title:Journal of Pediatric Endocrinology and Metabolism
language:en
Short-container-title:

Author:

Onuki Takanori¹^ORCID,Hiroaki Tadokoro¹,Sawano Kentaro¹,Shibata Nao¹,Nyuzuki Hiromi¹,Ogawa Yohei¹,Okada Masayasu²,Sone Hirohito³,Nagasaki Keisuke¹⁴^ORCID

Affiliation:

1. Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan

2. Department of Neurosurgery , Brain Research Institute, Niigata University , Niigata , Japan

3. Department of Hematology , Endocrinology and Metabolism, Niigata University Faculty of Medicine , Niigata , Japan

4. Life Science Research Center, Nagano Children’s Hospital, 3100 Toyoshina , Azumino 399-8288 , Japan

Abstract

Abstract Objectives GH-releasing peptide-2 (GHRP2) can be used for provocative growth hormone testing (GHT). Since it acts as a powerful stimulus for GH secretion, cut-off peak GH level in GHRP2 loading test (GHRP2T) is higher than in other GHT. Nevertheless, data on response at adolescents are limited. This report aimed to investigate peak GH levels in GHRP2T in adolescents. Methods Clinical data of adolescents after onset of puberty who underwent GHRP2T at our institution from May 2010 to March 2023 were collected retrospectively. Subjects were classified into three groups according to underlying diseases. Results A total of 23 patients were included: 12 in organic or genetic GHD (o/gGHD) group, three in idiopathic GHD (iGHD) group, and eight in short stature (SS) group. The median GH peak levels were 3.4 ng/mL in o/gGHD group, 88.9 ng/mL in iGHD group, and 90.1 ng/mL in SS group, indicating a robust response of GH peak levels in iGHD and SS groups. Two patients exceeded the cut-off for GHRP2T but below for other GHT, indicating the current cut-off for GHRP2T may miss some GHD patients. Conclusions The GH response to GHRP2T in adolescents except the o/gGHD group may be robustly responsive. For the correct diagnosis of GHD, the cut-off peak GH levels in GHRP2T in adolescents may require revisiting.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/jpem-2024-0115/pdf

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