Apparent diffusion coefficient (ADC) measurements and morphometric evaluation of the cranium in age-matched children with central precocious puberty
Author:
Düzkalır Hanife Gülden1ORCID, Söbü Elif2ORCID, Adıgüzel Karaoysal Özge1ORCID, Günbey Hediye Pınar1ORCID, Caliskan Emine3ORCID
Affiliation:
1. Department of Radiology , Kartal Dr. Lütfi Kırdar City Hospital , Istanbul , Türkiye 2. Department of Pediatric Endocrinology , Kartal Dr. Lütfi Kırdar City Hospital , Istanbul , Türkiye 3. Department of Pediatric Radiology, Kartal Dr. Lütfi Kırdar City Hospital , Istanbul , Türkiye
Abstract
Abstract
Objectives
Central precocious puberty (CPP) is one of the common reasons for referral to pediatric endocrinology. Magnetic resonance imaging (MRI) is used to rule out intracranial pathologies. However, there is insufficient information in the literature about bone marrow abnormalities on MRI in CPP cases. The aim of this study was to evaluate the apparent diffusion coefficient (ADC) values obtained from bone marrow diffusion weight images (DWI) of cranial bone structures and the status of sphenooccipital synchondrosis (SOS) in CPP.
Methods
MRI data from 6-to 9-year-old girls with CPP and a healthy control group were evaluated. Anthropometric data, FSH, LH, and oestradiol tests were recorded, and the relationship between SOS status, DWI-ADC values of the clivus, parietal bone, and occipital protuberance were compared.
Results
The study included 146 girls, 79 CPP, and 67 healthy aged 6–9 years (median: 8 (2)). The diagnosis age was 8.30 ± 0.8 years. The ADC values were significantly lower on CPP than normal controls (p=<0.05). In the CPP group, pattern 1 was found at 2 % (n=2), pattern 2 at 3.5 % (n=3), and pattern 3 at 3.5 % (n=3) in clivus sphenooccipital synchondrosis. There was no correlation between the mean parietal, occipital, and clivus ADC values and any variable (p>0.05).
Conclusions
DWI-MRI ADC analysis can be used as a quantitative radiological marker for early detection of CPP, even before changes in sphenooccipital synchondrosis.
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health
Reference42 articles.
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