The concordance between ultrasonographic stage of breast and Tanner stage of breast for overweight and obese girls: a school population-based study
Author:
Pan Dongxue12, Fu Simao3, Li Xiaoqing45, Yu Tingting45, Huang Sizhe6, Zhang Bihong2, Lai Xin12, Liu Yifan12, Yu Xiaodan7, Lin Cuilan2, Liu Shijian45ORCID
Affiliation:
1. The Second School of Clinical Medicine, Southern Medical University , Guangzhou City , Guangdong Province , P. R. China 2. BoAi Hospital of Zhongshan Affiliated to Southern Medical University , Zhongshan City , Guangdong Province , P. R. China 3. Zhongshan City People's Hospital of Sun-Yat-Sen University , Zhongshan City , Guangdong Province , P. R. China 4. School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai , P. R. China 5. Department of Clinical Epidemiology and Biostatistics , Children Health Advocacy Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai , P. R. China 6. Health Care Center for Primary and Secondary Schools , Zhongshan City , Guangdong province , P. R. China 7. Department of Developmental and Behavioral Pediatrics , Shanghai Children’s Medical Center,School of Medicine, Shanghai Jiao Tong University , Shanghai , P. R. China
Abstract
Abstract
Objectives
In this study, we evaluated the concordance between the ultrasonographic stage of breast (US B) and Tanner stage of breast (TS B) for overweight and obese girls based on a school population study.
Methods
We conducted multistage, stratified cluster, and random-proportional sampling and ultimately included 221 girls (aged 6–10 years).
Results
This study revealed that the concordance was poor (accuracy=0.19 (95% confidence interval: 0.14, 0.25)) between US B and TS B among the 221 participants. When our subjects were stratified by weight, we observed a weak association between US B and TS B in the thin/normal weight group (r=0.34, p=0.001) but not in the overweight (r=0.097, p=0.38) or obese groups (r=–0.19, p=0.206), and as the body mass index (BMI) z-score increased, the overestimation ratio of TS B increased. US B manifested a positive correlation with breast bud diameter (BD) (r=0.885, p<0.001), follicle-stimulating hormone (r=0.235, p=0.009), and luteinizing hormone (r=0.192, p=0.037), but this was not the case with TS B.
Conclusions
As the BMI z-score increased, the correlation between the two methods declined, and the overestimation ratio of TS B increased. US B is an objective and quantitative method used to evaluate breast development, and whether BD might replace US B as a routine diagnostic method to evaluate breast development in clinical practice needs to be confirmed in larger-sample studies.
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health
Reference30 articles.
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