Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity
Author:
Jürimäe Jaak1, Karvelyte Vita2, Remmel Liina1, Tamm Anna-Liisa3, Purge Priit1, Gruodyte-Raciene Rita2, Kamandulis Sigitas2, Maasalu Katre4, Gracia-Marco Luis5, Tillmann Vallo4
Affiliation:
1. Institute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu , Tartu , Estonia 2. Lithuanian Sports University , Kaunas , Lithuania 3. Tartu Health Care College , Tartu , Estonia 4. Institute of Clinical Medicine, Faculty of Medicine, University of Tartu , Tartu , Estonia 5. PROFITH (PROmoting FITness and Health through physical activity) Research Group, Department of Physical Education and Sports , Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada , Granada , Spain
Abstract
Abstract
Objectives
Sclerostin is an important regulator of bone mass involving the Wnt/β-catenin signalling pathway. Relatively few studies have investigated the relationships of circulating sclerostin levels with adiposity-related and muscle-related biochemical factors in individuals with increased energy metabolism. The aim of this study was to investigate the associations of circulating sclerostin with adipokines, myokines, osteokines and body composition values in lean adolescent females with increased physical activity.
Methods
A total of 73 adolescent females who were physically active and aged 14–18 years old participated in the study. Sclerostin, leptin, resistin, tumour necrosis factor (TNF)-α, interleukin (IL)-6, irisin, osteocalcin, C-terminal telopeptide of type I collagen (CTx), insulin-like growth factor (IGF)-1 and insulin were obtained from fasting blood samples. Body composition was measured by dual-energy X-ray absorptiometry (DXA) and analyzed for body fat mass, lean body mass, bone mineral content and muscle mass.
Results
Serum sclerostin (117.9 ± 60.3 pg/mL) was correlated with age, age at menarche, body fat, muscle mass, training activity, leptin, TNF-α, irisin, osteocalcin, CTx and IGF-1. Multivariate linear regression analysis demonstrated that fat mass (β = 0.434; p = 0.001), leptin (β = −0.308; p = 0.015), irisin (β = 0.227; p = 0.024) and CTx (β = 0.290; p = 0.031) were the most important predictors of serum sclerostin concentration.
Conclusions
Bone-derived sclerostin is associated with specific adipokine, myokine and osteokine values in lean adolescent females with increased physical activity. These results suggest that the interactions between bone, adipose and muscle tissues could also be associated with circulating sclerostin concentrations.
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health
Reference48 articles.
1. Daniele, G, Innier, D, Mari, A, Bruder, J, Fourcaudot, M, Pengou, Z, et al.. Sclerostin and insulin resistance in prediabetes: evidence of a cross talk between bone and glucose metabolism. Diabetes Care 2015;38:1509–17. https://doi.org/10.2337/dc14-2989. 2. Neumann, T, Hofbauer, LC, Rauner, M, Lodes, S, Kästner, B, Franke, S, et al.. Clinical and endocrine correlates of circulating sclerostin levels in patients with type 1 diabetes mellitus. Clin Endocrinol 2014;80:649–55. https://doi.org/10.1111/cen.12364. 3. Stanik, J, Kratzsch, J, Landgraf, K, Vogel, M, Thiery, J, Kiess, W, et al.. The bone markers sclerostin, osteoprotegerin, and bone-specific alkaline phosphatase are related to insulin resistance in children and adolescents, independent of their association with growth and obesity. Horm Res Pediatr 2019;91:1–8. https://doi.org/10.1159/000497113. 4. Wedrychowicz, A, Sztefko, K, Starzyk, JB. Sclerostin and its association with insulin resistance in children and adolescents. Bone 2019;120:232–8. 5. Wedrychowicz, A, Sztefko, K, Starzyk, JB. Sclerostin and its significance for children and adolescents with type 1 diabetes mellitus. Bone 2019;120:387–92.
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