Associated autoimmune thyroid diseases in children and adolescents with type one diabetes in Jordan
Author:
Odeh Rasha1ORCID, Gharaibeh Lobna2ORCID, Ibrahim Sarah1ORCID, Alassaf Abeer1ORCID
Affiliation:
1. Department of Pediatrics , School of Medicine, University of Jordan , Amman , Jordan 2. Pharmacological and Diagnostic Research Center , Faculty of Pharmacy, AI-Ahliyya Amman University , Amman , Jordan
Abstract
Abstract
Objectives
To investigate the prevalence of thyroid autoimmunity and related thyroid disorders among children and adolescents with type 1 diabetes in Jordan.
Methods
In a retrospective study, thyroid stimulating hormone and thyroid hormone (Free T4) levels were measured in 684 children with type 1 diabetes who presented to Jordan University Hospital between January 2012 and February 2021. Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TGAb) antibodies were measured in 526 and 438 subjects with type 1 diabetes, respectively.
Results
681 children were included in the study (52.4 % females, average current age 14.3 years, average age at diagnosis 8.0 years, and average diabetes duration 6.2 years). Of the whole group, 18 children (2.6 %) were diagnosed with subclinical hypothyroidism and 31 children (4.4 %) had overt hypothyroidism. Of those who were tested for TPOAb and TGAb, 22.6 and 23.1 % were positive respectively. Predictors for developing hypothyroidism were female sex and positive antibodies to glutamic acid decarboxylase.
Conclusions
Screening for associated thyroid autoimmunity in children and adolescents with type one diabetes from Jordan is advised with a special focus on females and those with positive antibodies to glutamic acid decarboxylase.
Funder
Deanship of Academic Research, University of Jordan
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health
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