Affiliation:
1. Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics , Pediatric Institute, Jagiellonian University Medical College , Kraków , Poland
Abstract
Abstract
Objectives
Coexistence of arterial hypertension (AH) in children with obesity increases morbidity and shortens life. Its role as an indicator of coexisting metabolic complications is however less known. The objective of the study was to compare metabolic profiles of children with obesity and with or without AH.
Methods
We included patients aged 10–18 with the BMI Z-score ≥2. Diagnosis of AH was based on the European Society of Hypertension criteria (2016). Metabolic profiles were assessed by glucose and insulin levels taken before and after glucose load, fasting levels of triglycerides (TG), total (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and HOMA-IR.
Results
Of 534 patients, 33.5% were diagnosed with AH. The AH patients, as compared to non-AH, had higher fasting insulin levels (22 vs. 19.7 mIU/L, p=0.04), HOMA-IR (4.5 vs. 4.0, p=0.029), and post-load glucose level (6.3 vs. 5.7, p=0.000041). No differences in the post-load insulin levels (113 vs. 100 mIU/L, p=0.056), fasting glucose (4.5 vs. 4.5 mmol/L, p=0.5), or lipids were found (TC: 4.4 vs. 4.4 mmol/L, p=0.9; LDL: 2.7 vs. 2.7, p=0.2; TG: 1.4 vs. 1.4 mmol/L, p=0.5; HDL: 1.1 vs. 1.2, p=0.3.
Conclusions
Concomitance of AH in children with obesity may be an indicator of coexisting metabolic complications.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health
Reference33 articles.
1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet 2017;390:2627–42. https://doi.org/10.1016/S0140-6736(17)32129-3.
2. World Health Organisation. Report of the commission on ending childhood obesity. In: Implementation plan: executive summary. Geneva: World Health Organization; 2017.
3. WHO Europe. Children Obesity Surveillance Initiative, Highlights 2015-17, Preliminary data; 2018. Available from: www.euro.who.int/__data/assets/pdf_file/0006/372426/wh14-cosi-factsheets-eng.pdf?ua=1.
4. Fryar, CD, Carroll, MD, Afful, J. Prevalence of overweight, obesity, and severe obesity among children and adolescents aged 2–19 years: United States, 1963–1965 Through 2017–2018. Division of Health and Nutrition Examination Surveys 2018.
5. Di Bonito, P, Licenziati, MR, Morandi, A, Maffeis, C, Miragilia del Giudice, E, Di Sessa, A, et al.. Screening for hypertension in young people with obesity: feasibility in the real life. Nutr Metabol Cardiovasc Dis 2022;32:1301–7.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献