DSD/intersex: historical context and current perspectives

Author:

Lee Peter A.1,Mazur Tom2,Houk Christopher P.3

Affiliation:

1. Penn State College of Medicine, Penn State Hershey Medical Center , Hershey , PA , USA

2. Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, State University of New York, John R. Oistei Children’s Hospital , Buffalo , NY , USA

3. Medical College of Georgia, Augusta University Medical Center , Augusta , GA , USA

Abstract

Abstract Intersex/Disorders/Differences of sex development conditions have been recognized for millennia. An organized approach was adopted in the 1960–70s using the philosophy that gender identity was fluid and malleable. Consequences of this approach were the lack of disclosure, stigmatization, and excessive surgery to “normalize” the genitalia. Often this led to quality of life issues for those patients. There have been many modifications in approach since then to avoid the problems noted. There is consensus on many of these changes (e.g. disclosure) but continued controversy on others (e.g. the benefits of early surgery). This review summarizes the historical context and the current areas of consensus and controversy.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health

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3. Wilkins, L. Abnormalities of sec differentiation. Classification, diagnosis, selection of rearing and treatment. Pediatrics 1960;26:846–57. https://doi.org/10.1542/peds.26.5.846.

4. Jost, A. Problems of fetal endocrinology: the gonadal and hypophyseal hormones. Recent Prog Horm Res 1953;8:379–418.

5. Rey, RA, Houk, CP, Witchel, S, Lee, PA. Disorders of sex development. Chapter 14. In: Gardner, DG, Shoback, D, editors. Greenspan’s basic and clinical endocrinology, 10th Edition, LANGE medical book. New York: McGraw Hill; 2018:501–47 pp.

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