Three pediatric cases of symptomatic hyponatremia in Prader–Willi syndrome-Reference-Cited by-同舟云学术

Three pediatric cases of symptomatic hyponatremia in Prader–Willi syndrome

Published:2022-07-12 Issue:10 Volume:35 Page:1302-1305
ISSN:0334-018X
Container-title:Journal of Pediatric Endocrinology and Metabolism
language:en
Short-container-title:

Author:

Oto Yuji¹,Murakami Nobuyuki¹,Nakagawa Ryo²,Itoh Masatsune³,Nagai Toshiro⁴,Matsubara Tomoyo¹

Affiliation:

1. Department of Pediatrics , Dokkyo Medical University Saitama Medical Center , Saitama , Japan

2. Department of Pediatrics , The University of Tokyo Hospital , Tokyo , Japan

3. Department of Pediatrics , Kanazawa Medical University , Kanazawa , Japan

4. Nakagawanosato Ryoiku Center , Saitama , Japan

Abstract

Abstract Objectives A recent large retrospective cohort study of cases of hyponatremia in Prader–Willi syndrome (PWS), conducted at nine reference centers, showed that severe hyponatremia was rare in PWS (0.5%); furthermore, all cases involved adults. Here, we describe three pediatric cases of severe hyponatremia in PWS, with neurological symptoms. Case presentation The cases involved two girls and one boy, and only one patient showed uniparental disomy. All patients had hyponatremia during infancy and presented with clinical symptoms, such as convulsions. All three patients improved with intravenous fluids and fluid restriction, with no sequelae. Conclusions We report three pediatric cases of symptomatic hyponatremia of unknown cause in PWS. In patients with PWS, especially those with neurological symptoms such as convulsions, it is necessary to take hyponatremia into consideration.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpem-2022-0127/pdf

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