Association of muscle mass and fat mass on low-density-lipoprotein cholesterol and triglyceride plasma concentration in children and adolescents-Reference-Cited by-同舟云学术

Association of muscle mass and fat mass on low-density-lipoprotein cholesterol and triglyceride plasma concentration in children and adolescents

Published:2021-07-19 Issue:10 Volume:34 Page:1273-1282
ISSN:0334-018X
Container-title:Journal of Pediatric Endocrinology and Metabolism
language:en
Short-container-title:

Author:

Martakis Kyriakos¹²³^ORCID,Stark Christina⁴,Rehberg Mirko²^ORCID,Jackels Miriam¹²,Schoenau Eckhard¹²,Duran Ibrahim¹^ORCID

Affiliation:

1. Center of Prevention and Rehabilitation - UniReha , University of Cologne, Medical Faculty and University Hospital , Cologne , Germany

2. Department of Pediatrics , University of Cologne, Medical Faculty and University Hospital , Cologne , Germany

3. Department for Pediatric Neurology , Epileptology and Social Pediatrics, Justus-Liebig University , UKGM , Giessen , Germany

4. Cologne Centre for Musculoskeletal Biomechanics, University of Cologne , Cologne , Germany

Abstract

Abstract Objectives Obesity has often been associated with high low-density-lipoprotein cholesterol (LDL-C) and triglyceride plasma concentrations, known risk factors for diabetes mellitus and cardiovascular disease. Study objective was to evaluate the association of LDL-C and triglyceride plasma concentration with muscle and fat mass in children and adolescents. Methods We analyzed data of the National Health and Nutrition Examination Survey (1999–2004) to estimate lean muscle and fat mass assessed by dual-energy X-ray absorptiometry (DXA) of participants whose lipid profiles had been examined. Fat mass was operationalized by DXA-determined fat mass index (FMI). Muscle mass was assessed by appendicular lean mass index (aLMI). High LDL-C and triglyceride concentration was defined as above 130 mg/dL. Results For the evaluation of the association of LDL-C and triglyceride plasma concentration with LMI and FMI Z-scores, the data of 2,487 children and adolescents (age 8–19 years) (984 females) were eligible. High aLMI showed no association with LDL-C or triglyceride concentration, but high FMI showed significant association with LDL-C and triglyceride plasma concentration in the bivariate regression analysis. Conclusions Isolated muscle mass increase may not be protective against high LDL-C and triglycerides plasma levels in children and adolescents. Thus, exercise may lead to risk factor reduction mainly through fat mass reduction.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpem-2021-0254/pdf

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