An endocrine perspective on menstrual suppression for adolescents: achieving good suppression while optimizing bone health

Author:

Lahoti Amit1ORCID,Yu Christine2,Brar Preneet Cheema3,Dalgo Austin4,Gourgari Evgenia5,Harris Rebecca6,Kamboj Manmohan K.7,Marks Seth8,Nandagopal Radha9,Page Laura10ORCID,Raman Vandana11,Reynolds Danielle G.12,Sarafoglou Kyriakie1314,Terrell Carrie15,Stanley Takara L.16

Affiliation:

1. Pediatric Endocrine Division , Le Bonheur Children’s Hospital and University of Tennessee Health Science Center , Memphis , TN , USA

2. Section of Adult and Pediatric Endocrinology, Diabetes, & Metabolism , University of Chicago , Chicago , IL , USA

3. Division of Pediatric Endocrinology and Diabetes , NYU Grossman School of Medicine , New York , NY , USA

4. Center for Bioethics and Health Equity , Le Bonheur Children’s Hospital and University of Tennessee Health Science Center , Memphis , TN , USA

5. Pediatric Endocrinology Division, Department of Pediatrics , Georgetown University , Washington, DC , USA

6. Division of Endocrinology , Boston Children’s Hospital , Boston , MA , USA

7. Section of Endocrinology, Department of Pediatrics , Nationwide Children’s Hospital at The Ohio State University , Columbus , OH , USA

8. Section of Pediatric Endocrinology and Metabolism, Department of Pediatrics and Child Health , Children’s Hospital HSC Winnipeg, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg , MB , Canada

9. Department of Medical Education and Clinical Sciences , Elson S. Floyd College of Medicine, Washington State University , Spokane , WA , USA

10. Division of Endocrinology, Department of Pediatrics , Duke University , Durham , NC , USA

11. University of Utah , Salt Lake City , UT , USA

12. Diabetes and Endocrinology Center , University of South Florida , Tampa , FL , USA

13. Division of Pediatric Endocrinology, Department of Pediatrics , University of Minnesota Masonic Children’s Hospital , Minneapolis , MN , USA

14. Department of Experimental and Clinical Pharmacology , University of Minnesota College of Pharmacy , Minneapolis , MN , USA

15. Division of General Obstetrics , Gynecology, Midwifery and Family Planning at the University of Minnesota Medical School , Minneapolis , MN , USA

16. Pediatric Endocrine Unit and Metabolism Unit , Massachusetts General Hospital and Harvard Medical School , Boston , MA , USA

Abstract

Abstract Suppression of menstruation and/or ovarian function in adolescent girls may be desired for a variety of reasons. Numerous medical options exist. The choice of the appropriate modality for an individual patient depends on several factors based on differences in the efficacy of achieving menstrual suppression as well as in their side effect profiles. Adolescence is also a period of bone mass accrual in girls, and several of these modalities may negatively influence peak bone mass. This review focuses on the efficacy of achieving menstrual suppression and the effect on bone health of the various options through an overview of the current literature and also highlights areas in need of further research.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health

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