Etiologies, profile patterns and characteristics of children with short stature in Jordan
Author:
Alassaf Abeer1, Gharaibeh Lobna2, Ibrahim Sarah1, Odeh Rasha1
Affiliation:
1. Department of Pediatrics , The University of Jordan , Amman , Jordan 2. Pharmacological and Diagnostic Research Center, Faculty of Pharmacy , Al-Ahliyya Amman University , Amman , Jordan
Abstract
Abstract
Objectives
Childhood growth influences their social and psychological behavior, and abnormal growth may reflect underlying pathological etiologies. It is important to diagnose children with short stature as early as possible to be able to manage treatable causes. We aim to study etiologies and characteristics of short stature in children in Jordan.
Methods
This is a cross-sectional retrospective review of the medical records of children diagnosed with short stature at a referral university hospital. Clinical characteristics, auxological, laboratory, and radiological investigations were collected and analyzed.
Results
Among a total of 551 children diagnosed with short stature, the number of boys was significantly higher than girls, 304 (55.2%) and 247 (44.8%), respectively with a p-value of 0.015. Average age at presentation for all patients was 10.24 ± 3.23, with no significant difference between boys and girls. Pathological etiology was higher than normal variants 55.7 and 44.3%, respectively with p=0.007. Constitutional delay of growth and puberty (CDGP) was the most frequent cause in the normal variant group, 59.8%. Among the pathological group, the most common etiology was growth hormone deficiency (32.2%) with mean age of presentation of 9.40 years and was not significantly different from the age in other etiological groups, 9.44 years and p=0.931.
Conclusions
Growth monitoring of children should start at an early age for boys and girls. Referral to the pediatric endocrine clinic should be considered when growth problems are suspected for accurate diagnosis and etiology profiling.
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health
Reference40 articles.
1. Maghnie, M, Labarta, JI, Koledova, E, Rohrer, TR. Short stature diagnosis and referral. Front Endocrinol (Lausanne) 2018;8:374. https://doi.org/10.3389/fendo.2017.00374. 2. Rogol, AD, Hayden, GF. Etiologies and early diagnosis of short stature and growth failure in children and adolescents. J Pediatr 2014;164:S1–14. https://doi.org/10.1016/j.jpeds.2014.02.027. 3. Forrest, CB, Glade, GB, Baker, AE, Bocian, AB, Kang, M, Starfield, B. The pediatric primary-specialty care interface: how pediatricians refer children and adolescents to specialty care. Arch Pediatr Adolesc Med 1999;153:705–14. https://doi.org/10.1001/archpedi.153.7.705. 4. Stabler, B, Clopper, RR, Siegel, PT, Stoppani, C, Compton, PG, Underwood, LE. Academic achievement and psychological adjustment in short children. The National Cooperative Growth Study. J Dev Behav Pediatr 1994;15:1–6. https://doi.org/10.1097/00004703-199402000-00001. 5. Kranzler, JH, Rosenbloom, AL, Proctor, B, Diamond, FBJr, Watson, M. Is short stature a handicap? A comparison of the psychosocial functioning of referred and nonreferred children with normal short stature and children with normal stature. J Pediatr 2000;136:96–102. https://doi.org/10.1016/s0022-3476(00)90057-x.
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