Chemical constituents from <i>Ficus sur</i> Forssk (Moraceae)-Reference-Cited by-同舟云学术

Chemical constituents from Ficus sur Forssk (Moraceae)

Published:2022-11-03 Issue:5-6 Volume:78 Page:201-207
ISSN:0939-5075
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Ngoh Misse Mouelle Eitel¹,Foundikou Nsangou Mohamed¹,Michiren Mandou Vanini Samiyatou¹,Wansi Jean Duplex¹,Akone Sergi Herve¹²,Ngeufa Happi Emmanuel¹

Affiliation:

1. Department of Chemistry, Faculty of Science , University of Douala , P.O. Box 24157 Douala , Cameroon

2. Department of Microbial Natural Products (MINS), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) , University of Saarland , D-66123 Saarbrücken , Germany

Abstract

Abstract Phytochemical investigation of the aerial roots of Ficus sur, a Cameroonian medicinal plant, resulted in a previously undescribed cerebroside, suroside (1), in addition to its aglycon congener suramide (2). Moreover, six known natural products including alpinumisoflavone (3), wighteone metabolite (4), oleanolic acid (5), β-sitosterol (6), β-sitosterol-3-O-β-D-glucopyranoside (7), and epi-ѱ-taraxastanolone (8) were identified. The structures of the previously undescribed compounds were determined by analysis of 1D and 2D-NMR (One and two dimensional nuclear magnetic resonance), mass spectrometry, chemical conversion, and by comparison of these data with those from the literature. Wighteone metabolite (4) exhibited a weak cytotoxic activity against the human HepG2 hepatocellular carcinoma cells with an IC50 value of 51.9 µM.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2022-0165/pdf

Reference40 articles.

1. Rafael, MP, Marcela, GD, Bruno, SAFB, Gustavo, PC, Maria, GLB, Guilherme, O. Medicinal plants recommended by the World Health Organization: DNA barcode identification associated with chemical analyses guarantees their quality. PLoS One 2015;10:5. https://doi.org/10.1371/journal.pone.0127866.

2. Victor, K, Thomas, E. Cameroonian medicinal plants: pharmacology and derived natural products. Front Pharmacol 2010;1:123. https://doi.org/10.3389/fphar.2010.00123.

3. Jean, MT, Xavier, SN, Edwige, LN, Franck, M, Rene, W, Michelle, I, et al.. Biological activities of plant extracts from Ficus elastica and Selaginella vogelli: an antimalarial, antitrypanosomal and cytotoxity evaluation. Saudi J Biol Sci 2018;25:117–22. https://doi.org/10.1016/j.sjbs.2017.07.002.

4. Enitome, EB, Jennifer, M, Edward, GR, RuAngelie, E-E. Characterisation of the antiproliferative constituents and activity of Ficus exasperata (Vahl) on ovarian cancer cells – a preliminary investigation. Nat Prod Res 2017;31:2164–8. https://doi.org/10.1080/14786419.2016.1277348.

5. Fidele, N-K, Lydia, LL, Luc, MM, Nnange, E, Luc, COO, Eugene, M, et al.. Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification. BMC Compl Alternative Med 2013;13:147. https://doi.org/10.1186/1472-6882-13-147.