Author:
Samadi Afshin,Ansari Mohammad Hassan Khadem,Ulusu Nuriye Nuray
Abstract
AbstractBackground:A large number of psychotropic drugs can interfere with the thyroid physiology, function and autoimmunity.Objective:The aim of the present study was to investigate the effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin (aTg), antithyroid peroxidase, and thyroid stimulating hormone levels on rats.Materials and Methods:First group of adult male Wistar rats was the control, second group received 0.5 mg kgResults:We have investigated a decrease in aTg amounts of control group (5.461±0.718) compared with drug treated rats with alprazolam (1.433±0.225) and haloperidol (1.21±0.228). (PConclusion:We found that these two drugs may interfere with the thyroid physiology and metabolism.
Subject
Biochemistry (medical),Clinical Biochemistry,Molecular Biology,Biochemistry
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