Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population

Abstract

Abstract Objectives: The association between manganese superoxide dismutase (MnSOD) p.Val16Ala polymorphism and cancer has been shown in various studies. The aim of this study is to investigate the relationship between MnSOD polymorphism (V/V, V/A, A/A) and cancer in the Turkish and Cypriot population through meta-analysis. Material and methods: The present study included meta-analysis of 14 publications covering 2413 cancer patients and 2907 healthy control groups from 2005 to 2016. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using the random effect model of DerSimonian and Laird for each study. Publication bias was checked with funnel plot by Begg’s and Egger’s test statistics. Results: Meta-analysis of MnSOD polymorphism was performed in the additive model (AV vs. VV; OR=1.133, 95% CI: 1.002–1.282), allele contrast (A vs. V; OR=1.016, 95% CI: 0.930–1.278), homozygote model (AA vs. VV; OR=0.983, 95% CI: 0.839–1.153), dominant model (AA+AV vs. VV; OR=1.090, 95% CI: 0.971–1.223) and recessive model (AA vs. AV+VV; OR=0.924, 95% CI: 0.803–1.064). The A/V genotype polymorphism was found be significant for cancer. Conclusion: The frequency of the A/V heterozygote genotype of the MnSOD polymorphisms is found to be higher in the Cypriot and Turkish populations than any other genotype.