Reactions with Aziridines, 37 [1]. N,N'-Substituted 1,1-Dimethylethylenediamines by Highly Regioselective Ring Opening of Activated 2,2-Dimethylaziridines through Aliphatic Amines

Abstract

Secondary and primary aliphatic amines 2 form regioselectively N,N '-substituted 1,1-dimethylethylenediamines by reaction with activated 2,2-dimethylaziridines 1. The kind of activation (X in 1), determines the mode of ring opening: X = sulfonyl gives structure 3, X = acyl or 2,4- dinitrophenyl structure 4.