Carbontetrachloride induced acute liver damage and protective effect of n-acetylcysteine on rats with regenerated and non-regenerated liver / Karaciğeri rejenere olan ve olmayan sıçanlarda, karbontetraklorürle indüklenen akut karaciğer hasarı ve n-asetilsisteinin koruyucu etkisi

Abstract

AbstractObjective: Our aim was to investigate 70% partial hepatectomy (PH) groups, compare with not subjected to PH groups after exposure to hepatotoxic agents for alterations in the protective effects of antioxidant agents and sensitivity of the liver. Accordingly, we aimed to investigate the toxicity of a hepatotoxic agent, carbon tetrachloride (CClMethods: 67 male Wistar Albino rats were divided into 2 main groups to total 9 subgroups: group 1, underwent PH; group 2, not subjected to PH. 0.5 ml/kg CClResults: Catalase (CAT) and superoxide dismutase (SOD) activities were significantly lower in both groups when CClConclusion: These results indicated that CCl