A rare cause of hyperamylasemia: multiple myeloma

Abstract

AbstractBackground:A higher amylase than normal concentration may reflect one of several medical conditions, including acute inflammation of the pancreas, perforated peptic ulcer, torsion of an ovarian cyst, strangulation ileus, mesenteric ischemia, macroamylasemia, renal failure and mumps. In addition; amylase production by epithelial carcinomas has been well documented. But hyperamylasemia associated with multiple myeloma has been reported only in a few cases. We report a case with hyperamylasemia associated with multiple myeloma in this paper because of rarity.Case report:We report a 64 year old male patient with multiple myeloma. He had hyperamylasemia and no evidence of pancreatic and salivary gland disease, renal failure. The patient had relapse disease after autologous bone marrow transplant. Amylase value is high correlated with his disease status. Combined chemotherapy (lenalidomide 25 mg once daily orally on days 1–21 and dexamethosone 40 mg/day, days 1–4 of repeated 28-day cycles) was started to our patient for multiple myeloma. The amylase level decresed to a normal level after 28 days.Conclusion:Paraneoplastic hyperamylasaemia as a marker to monitor disease progression and treatment response in cases with multiple myeloma. It related to extensive extra-medullary spread, extensive bone destruction and shorter survival time.