Twin pregnancy in uteri with congenital anomalies: prenatal diagnosis by three- dimensional ultrasound

Abstract

Abstract Objectives To establish a practical and valid method for the diagnosis of twin gestation in uteri with Müllerian anomalies in the first trimester of pregnancy. Case presentation This was a prospective cohort study. Two cases with congenital uterine anomalies were followed prospectively from 7 weeks of gestation and compared to eight controls. The longitudinal to transverse uterine lumen diameter ratio (LTDR) was measured in mid-sagittal and coronal planes. The LTDR was compared between unicornuate and didelphys uteri to normal uteri controls weekly. The area under the curve for the coronal and sagittal planes were 1.000 and 0.823, respectively. For the coronal plane, an LTDR of 1.15 was selected as optimal for predicting uteri with a Müllerian anomaly, with a sensitivity of 100%, specificity of 100%. An LTDR of 1.68 in the sagittal plane was selected as optimal for predicting anomalous uteri, with a sensitivity of 100%, specificity of 73%. Conclusions LTDR ratios measured in mid sagittal and coronal planes of unicornuate and didelphys uteri with twin gestation during the first trimester of pregnancy are highly predictive of Müllerian anomalies. Early diagnosis of uterine anomalies could provide a reference to initiate earlier meticulous follow-up.