Chemical composition and anticholinesterase inhibitory activity of Pavetta graciliflora Wall. ex Ridl. essential oil

Author:

Salleh Wan Mohd Nuzul Hakimi Wan1ORCID,Khamis Shamsul2

Affiliation:

1. Department of Chemistry, Faculty of Science and Mathematics , Universiti Pendidikan Sultan Idris (UPSI) , 35900 Tanjong Malim, Perak , Malaysia , Phone: +6015-48797123

2. School of Environmental and Natural Sciences, Faculty of Science and Technology , Universiti Kebangsaan Malaysia , 43600 Bangi, Selangor , Malaysia

Abstract

Abstract Chemical composition and anticholinesterase activity of the essential oil of Pavetta graciliflora Wall. ex Ridl. (Rubiaceae) was examined for the first time. The essential oil was obtained by hydrodistillation and was fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 20 components were identified in the essential oil, which made up 92.85% of the total oil. The essential oil is composed mainly of β-caryophyllene (42.52%), caryophyllene oxide (25.33%), β-pinene (8.67%), and α-pinene (6.52%). The essential oil showed weak inhibitory activity against acetylcholinesterase (AChE) (I%: 62.5%) and butyrylcholinesterase (BChE) (I%: 65.4%) assays. Our findings were shown to be very useful for the characterization, pharmaceutical, and therapeutic applications of the essential oil from P. graciliflora.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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