Author:
Sychev Dmitry A.,Zastrozhin Mikhail S.,Miroshnichenko Igor I.,Baymeeva Natalia V.,Smirnov Valery V.,Grishina Elena A.,Ryzhikova Kristina A.,Mirzaev Karin B.,Markov Dmitry D.,Skryabin Valentin Y.,Snalina Nataliya E.,Nosikova Polina G.,Savchenko Ludmila M.,Bryun Evgeny A.
Abstract
AbstractBackground:Haloperidol is used for the treatment of alcohol use disorders in patients with signs of alcohol-related psychosis. Haloperidol therapy poses a high risk of adverse drug reactions (ADR). Contradictory data, which include the effects of genetic polymorphisms in genes encoding the elements of haloperidol biotransformation system on haloperidol metabolism rate and plasma drug concentration ratio, are described in patients with different genotypes. The primary objective of this study was to investigate the effects ofMethods:The study included 69 male patients with alcohol use disorder. Genotyping was performed using the allele-specific real-time PCR.Results:Results indicated that both C/D indexes and equilibrium concentration levels depend onConclusions:The study demonstrates that
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Cited by
16 articles.
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