Author:
Methaneethorn Janthima,Panomvana Duangchit,Vachirayonstien Thaveechai
Abstract
AbstractBackground:Therapeutic drug monitoring is essential for both phenytoin and phenobarbital therapy given their narrow therapeutic indexes. Nevertheless, the measurement of either phenytoin or phenobarbital concentrations might not be available in some rural hospitals. Information assisting individualized phenytoin and phenobarbital combination therapy is important. This study’s objective was to determine the relationship between the maximum rate of metabolism of phenytoin (VMethods:Data on phenytoin and phenobarbital concentrations of 19 epileptic patients concurrently receiving both drugs were obtained from medical records. Phenytoin and phenobarbital pharmacokinetic parameters were studied at steady-state conditions. The relationship between the elimination parameters of both drugs was determined using simple linear regression.Results:A high correlation coefficient between VConclusions:Regression equations were established for estimating V
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
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