Half-inhibition Concentrations of New Cholinesterase Inhibitors-Reference-Cited by-同舟云学术

Half-inhibition Concentrations of New Cholinesterase Inhibitors

Published:2004-04-01 Issue:3-4 Volume:59 Page:293-296
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Zdražilová Pavla¹,Štĕpánková Šárka²,Komers Karel¹,Ventura Karel²,Čegan Alexander³

Affiliation:

1. Faculty of Chemical Technology, University of Pardubice, Department of Physical Chemistry, nám. Čs. legií 565, 532 10 Pardubice, Czech Republic

2. Department of Analytical Chemistry, University of Pardubice, nám. Čs. legií 565, 532 10 Pardubice, Czech Republic

3. Department of Biological and Biochemical Sciences, University of Pardubice, Štrossova 239, 532 10 Pardubice, Czech Republic

Abstract

The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer’s disease treatment - rivastigmine and galanthamine.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2004-3-430/pdf

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