Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases

Author:

Sambataro Gianluca12,Sambataro Domenico12,Orlandi Martina3,Battisti Sofia4,Cavagna Lorenzo5,Sverzellati Nicola6,Silva Mario6,Palmucci Stefano7,Colaci Michele2,Malatino Lorenzo2,Ariani Alarico8

Affiliation:

1. Artroreuma SRL, Outpatient of Rheumatology Accredited with Italian National Health System , Mascalucia , Catania , Italy

2. Department of Clinical and Experimental Medicine , University of Catania , Catania , Italy

3. Department of Experimental and Clinical Medicine , University of Florence , Florence , Italy

4. Department of Radiology , AUSL Romagna “M. Bufalini” Hospital , Cesena , Italy

5. Division of Rheumatology , University and IRCCS “Policlinico San Matteo” Fundation , Pavia , Italy

6. Department of Medicine and Surgery, Section of Radiology , University of Parma , Parma , Italy

7. Department of Medical Surgical Sciences and Advanced Technologies “GF Ingrassia” , University Hospital “Policlinico Vittorio Emanuele”, University of Catania , Catania , Italy

8. Department of Medicine, Internal Medicine and Rheumatology , Azienda Ospedaliero Universitaria di Parma , Parma , Italy

Abstract

Abstract Objectives Quantitative computed tomography (QCT) is a promising tool for objective assessment of interstitial lung disease (ILD) related to connective tissue diseases (CTD). However, its validity was never investigated. The aim of this study was to assess QCT feasibility, face, and content validity evaluation concerning CTD-ILD. Methods A rheumatologist and a chest radiologist conceived an online survey with nine statements: Two about general issue involving CTD-ILD, one for the face validity, three both for content validity and feasibility. Each statement had to be rated with a score from 0 to 100, respectively, (complete disagreement and agreement). We considered a statement supported by the experts if the median score was ≥75.0. Results A panel of 14 experts (11 from Europe, three from America) with a nine years median experience was enrolled. All the statements about feasibility, face and content validity were supported, except for QCT capability to recognize elementary lesions. Conclusions The panel of experts supported feasibility, face, and content validity of QCT assessment concerning CTD-ILD. This may stimulate a greater use in clinical practice and further studies to confirm its discriminative properties and its construct validity.

Publisher

Walter de Gruyter GmbH

Subject

Drug Discovery,Pharmacology,General Medicine,Physiology

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