Author:
Alagbonsi Isiaka A.,Olayaki Luqman A.,Salman Toyin M.
Abstract
AbstractThe mechanisms involved in the spermatotoxic effect ofFifty-five (55) male albino rats (250–300 g) were randomly divided in a blinded fashion into five oral treatment groups as follows: group I (control, n=5) received 1 mL/kg of 10% ethanol for 30 days; groups IIa, IIb, and IIc (n=5 each) received 2 mg/kgCannabis treatments reduced the Johnsen score, sperm count, motility, morphology, paired testicular/body weight ratio, and total antioxidant capacity, but increased lactate dehydrogenase activity. In addition, supplementation of cannabis-treated rats with either melatonin or vitamin C exacerbates the effect of cannabis on those parameters, whereas combination of melatonin and vitamin C reversed the trend to the level comparable to control.This study further showed the gonadotoxic effect of
Subject
Drug Discovery,Pharmacology,General Medicine,Physiology
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