Phellinus rimosus improves mitochondrial energy status and attenuates nephrotoxicity in diabetic rats

Author:

Rony K.A.,Ajith T.A.,Kuttikadan Tony A.,Blaze R.,Janardhanan K.K.

Abstract

AbstractBackground:Mitochondrial dysfunction and increase in reactive oxygen species during diabetes can lead to pathological consequences in kidneys. The present study was aimed to investigate the effect ofMethods:(50 and 250 mg/kg, p.o) was treated after inducing diabetes by STZ (45 mg/kg, i.p) in rats. The serum samples were subjected to creatinine and urea estimation. Mitochondrial antioxidant status such as mitochondrial superoxide dismutase, glutathione peroxidase, and reduced glutathione; adenosine triphosphate level; and lipid peroxidation were measured. The activities of Krebs cycle enzymes such as isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase as well as mitochondrial complexes I, III, and IV in kidney mitochondria were also determined.Results:Administration ofConclusions:The results of the study concluded that by limiting the extent of renal mitochondrial damage in the hyperglycemic state,

Publisher

Walter de Gruyter GmbH

Subject

Drug Discovery,Pharmacology,General Medicine,Physiology

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