Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test-Reference-Cited by-同舟云学术

Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test

Published:2015-01-01 Issue:1 Volume:26 Page:
ISSN:2191-0286
Container-title:Journal of Basic and Clinical Physiology and Pharmacology
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Author:

Oshikoya Kazeem Adeola,Smith Kenneth,Sammons Helen,Choonara Imti

Abstract

AbstractHepatic metabolism of drugs has been rarely studied in children with malnutrition. Caffeine breath test (CBT) has been used to determine the activity of cytochrome P450 1A2 (CYP1A2) enzymes in children. We used the CBT to assess how marasmus and kwashiorkor differentially affectA total of 45 children composed of 15 children per group of malnutrition (marasmus, marasmic-kwashiorkor, and kwashiorkor) were studied during malnutrition and after nutritional recovery. After an overnight fast, patients ingested 3 mg/kgThe CPDR in the expiredHepatic metabolism of caffeine significantly decreased in children with marasmus, marasmic-kwashiorkor, and kwashiorkor compared to after they had recovered nutritionally. This suggests a decreased CYP1A2 activity in all categories of malnutrition.

Publisher

Walter de Gruyter GmbH

Subject

Drug Discovery,Pharmacology,General Medicine,Physiology

Link

https://www.degruyter.com/view/j/jbcpp.2015.26.issue-1/jbcpp-2013-0081/jbcpp-2013-0081.pdf

Reference72 articles.

1. United Children s Fund World The UNICEFWHO Joint Child Malnutrition Estimates New York UNICEF WHO The Available at http www who int nutgrowthdb jme unicef who wb pdf Accessed;Nations;Health Organization World Bank World Bank World Bank,2012

2. Rapid sample throughput for biomedical stable isotope tracer studies;Preston;Biomed Environ Mass,1988

3. Case management of HIV - infected severely malnourished children : challenges in the area of highest prevalence;Heikens;Lancet,2008

4. Pharmacokinetics of metronidazole in severely malnourished and nutritionally rehabilitated children;Lares;Clin Pharmacol Ther,1992

5. Effect of Casilan on caffeine metabolism in overnight - fasted healthy Nigerian children;Oshikoya;Pharmacol,2013

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