Lipid profile and mortality in patients with pulmonary thromboembolism; a systematic review and meta-analysis

Author:

Roshanravan Neda1ORCID,Seyed Ghiasi Nikan2ORCID,Ghaffari Samad1ORCID,Ghasemnezhad Saadatlou Saeid2ORCID,Seifimansour Sina3,Hamzezadeh Sina2ORCID,Naseri Amirreza24ORCID,Ghanivash Amin1ORCID,Mosharkesh Erfan2ORCID,Nasiri Ehsan2ORCID,Javanshir Elnaz1ORCID,Banisefid Erfan2ORCID

Affiliation:

1. Cardiovascular Research Center , 48432 Tabriz University of Medical Sciences , Tabriz , Iran

2. Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran

3. Student Research Committee, School of Medicine , Ardabil University of Medical Sciences , Ardabil , Iran

4. Research Center for Evidence Based‐Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence , Tabriz University of Medical Sciences , Tabriz , Iran

Abstract

Abstract Introduction Acute pulmonary thromboembolism (PTE) is a life-threatening disease. Considering the availability and accessibility of assessing the serum lipids, this study aims to define the predictive value of lipid profile, as well as the history of lipid disorders, for the mortality of PTE patients. Content Clinical studies, in which the relation of lipid profile, including triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol, as well as history of imbalance of lipids, with mortality of PTE patients was reported, were included. Non-English articles, reviews, letters, editorials, and non-English papers were excluded. A systematic search was conducted in PubMed, Embase, Scopus, and Web of Science databases. The risk of bias was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal tools and CMA 4 was utilized for the quantitative synthesis. Out of 3,724 records, six studies were included in this systematic review. Lipid profile is suggested as a prognostic marker for survival in patients with PTE so higher initial serum HDL, LDL, and total cholesterol levels were associated with lower mortality rates in PTE patients. In addition, dyslipidemia was found to be associated with mortality of PTE patients. Based on the quantitative synthesis, there was a greater serum level of HDL in the survival group (standardized mean difference: −0.98; 95 % CI: −1.22 to −0.75; p-value<0.01). Summary and Outlook Mortality is lower in PTE patients with greater serum lipid levels; therefore, the early prognosis of PTE may be ascertained by measuring serum lipids within the first 24 h of admission.

Publisher

Walter de Gruyter GmbH

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3