Lipid profile and mortality in patients with pulmonary thromboembolism; a systematic review and meta-analysis
Author:
Roshanravan Neda1ORCID, Seyed Ghiasi Nikan2ORCID, Ghaffari Samad1ORCID, Ghasemnezhad Saadatlou Saeid2ORCID, Seifimansour Sina3, Hamzezadeh Sina2ORCID, Naseri Amirreza24ORCID, Ghanivash Amin1ORCID, Mosharkesh Erfan2ORCID, Nasiri Ehsan2ORCID, Javanshir Elnaz1ORCID, Banisefid Erfan2ORCID
Affiliation:
1. Cardiovascular Research Center , 48432 Tabriz University of Medical Sciences , Tabriz , Iran 2. Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran 3. Student Research Committee, School of Medicine , Ardabil University of Medical Sciences , Ardabil , Iran 4. Research Center for Evidence Based‐Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence , Tabriz University of Medical Sciences , Tabriz , Iran
Abstract
Abstract
Introduction
Acute pulmonary thromboembolism (PTE) is a life-threatening disease. Considering the availability and accessibility of assessing the serum lipids, this study aims to define the predictive value of lipid profile, as well as the history of lipid disorders, for the mortality of PTE patients.
Content
Clinical studies, in which the relation of lipid profile, including triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol, as well as history of imbalance of lipids, with mortality of PTE patients was reported, were included. Non-English articles, reviews, letters, editorials, and non-English papers were excluded. A systematic search was conducted in PubMed, Embase, Scopus, and Web of Science databases. The risk of bias was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal tools and CMA 4 was utilized for the quantitative synthesis. Out of 3,724 records, six studies were included in this systematic review. Lipid profile is suggested as a prognostic marker for survival in patients with PTE so higher initial serum HDL, LDL, and total cholesterol levels were associated with lower mortality rates in PTE patients. In addition, dyslipidemia was found to be associated with mortality of PTE patients. Based on the quantitative synthesis, there was a greater serum level of HDL in the survival group (standardized mean difference: −0.98; 95 % CI: −1.22 to −0.75; p-value<0.01).
Summary and Outlook
Mortality is lower in PTE patients with greater serum lipid levels; therefore, the early prognosis of PTE may be ascertained by measuring serum lipids within the first 24 h of admission.
Publisher
Walter de Gruyter GmbH
Reference39 articles.
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