Clinical implications of anti-idiotype antibodies in COVID-19
Author:
Shukla Ajay Kumar1, Misra Saurav2
Affiliation:
1. Department of Pharmacology , AIIMS , Bhopal , India 2. Department of Pharmacology , Kalpana Chawla Government Medical College , Karnal , India
Abstract
Abstract
Idiotype-based therapeutics have failed to deliver their promise, necessitating rethinking of the concept and its potential to develop a viable immunotherapy method. The idiotype based hypothesis is discussed in this paper in order to produce effective anti-idiotype vaccinations. Polyclonal anti-idiotype reagents have been shown to be more successful in animal models, and a better understanding of the immune response in humans supports the idea that polyclonal anti-idiotype vaccines will be more effective than monoclonal-based anti-idiotype vaccines. This innovative approach can be used to produce therapeutic antibodies in a Biotech-standard manner. The idiotype network has been tweaked in the lab to provide protection against a variety of microbiological diseases. Antibodies to image-idiotype antigens, both internal and non-internal, can elicit unique immune responses to antigens. The current outbreak of severe acute respiratory syndrome 2 (SARS-2) has presented a fantastic chance to use idiotype/anti-idiotype antibodies as a protective regimen, which might be used to treat COVID-19 patients. The development of various effective vaccinations has been crucial in the pandemic’s management, but their effectiveness has been limited. In certain healthy people, the development of viral variations and vaccinations can be linked to rare off-target or hazardous effects, such as allergic responses, myocarditis and immune-mediated thrombosis and thrombocytopenia. Many of these occurrences are most likely immune-mediated. The current analysis reveals successful idiotype/anti-idiotype antibody uses in a variety of viral illnesses, emphazising their importance in the COVID-19 pandemic.
Publisher
Walter de Gruyter GmbH
Subject
Drug Discovery,Pharmacology,General Medicine,Physiology
Reference40 articles.
1. Zumla, A, Chan, JF, Azhar, EI, Hui, DS, Yuen, KY. Coronaviruses—drug discovery and therapeutic options. Nat Rev Drug Discov 2016;15:327–47. https://doi.org/10.1038/nrd.2015.37. 2. Lu, R, Zhao, X, Li, J, Niu, P, Yang, B, Wu, H, et al.. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020;395:565–74. https://doi.org/10.1016/s0140-6736(20)30251-8. 3. Xu, Z, Shi, L, Wang, Y, Zhang, J, Huang, L, Zhang, C, et al.. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020;8:420–2. https://doi.org/10.1016/s2213-2600(20)30076-x. 4. Neuman, BW, Adair, BD, Yoshioka, C, Quispe, JD, Orca, G, Kuhn, P, et al.. Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. J Virol 2006;80:7918–28. https://doi.org/10.1128/jvi.00645-06. 5. Beniac, DR, Andonov, A, Grudeski, E, Booth, TF. Architecture of the SARS coronavirus prefusion spike. Nat Struct Mol Biol 2006;13:751–2. https://doi.org/10.1038/nsmb1123.
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